Comparative antimicrobial and antifungal activity of medicinal plants extract against microbes and dermatophytes

Bacterial and fungal infections are some of the most serious global health issues of the present century. The objective of the present investigation was to develop poly herbal medical compound to treat various bacterial and fungal infections. The alcoholic extracts were prepared from Andrographis paniculata whole plant, Phyla nodiflora whole plant, Psoralea corylifolia seeds, and Piper cubeba seeds. The alcoholic extracts of various plants were tested for antimicrobial and antidermatophytic infections and antifungal efficiency applying agar disc diffusion method. Ciprofloxacin and Ketoconazole were used as standard for above activities. The activity was carried out in combination of extracts and also done alone to know the action potential of extracts. The study revealed that of the combination of Phyla nodiflora and Andrographis paniculata possess maximum zone of inhibition when compared to other plants extracts. In case of antimicrobial activity the efficiency was shown by combination of Psoralea corylifolia and Piper cubeba

Qsar studies of side chain modified DI and TRI-peptides in mimicking the Bio-potency of anti-nociceptive action of enkephalin

QSAR Studies of smaller chain peptides has been proposed for predicting enkephalin mimic anti-nociceptive activity using a lipophilic parameter partition coefficient. C Log P Program was developed basically based on the fragmentation approach, has been written in Fortran IV. The test compounds, Ile-Val, Phe-Gly, Asn-Cys, Gly-Cys-Val and Ile-Val-Glu were encoded as topological representation of molecular structures using alpha numeric language smiles notation. Log P values obtained for the smaller chain dipeptides and tri-peptides were -0.481 [Ile-Val]; -1.757 [Phe-Gly]; -4,159 [Asn-Cys]; -2.318 [Gly-Cys-Val] and -1.627 [Ile-Val-Glu]. Substitution of glycyl or L-amino acid residues by D-amino acids at appropriate sites of some bioactive peptides may cause a considerable rise in potency. The effect is most dramatic at the Gly-position of enkephalin. Drugs which are to be targeted for the CNS should have log P value of approximately 2. Hence it was concluded that Phe-Gly and Gly-Cys-Val are selected as potential targets for enkephalin like anti-nociceptive activity